Where do genes come from? – Carl Zimmer

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The lesson “Where Do Genes Come From?” explains that genes, which serve as instruction manuals for various biological functions, originated from simple microbes that existed around 4 billion years ago. Over time, genes have evolved through processes such as duplication and mutation, leading to the emergence of new genes that can perform different functions, like the adaptation seen in snakes’ venom production. The lesson highlights the ongoing nature of gene development, suggesting that as life continues on Earth, new genes will keep evolving.

Where Do Genes Come From?

Did you know that your DNA contains about 20,000 genes? These genes are like tiny instruction manuals that tell your body how to make everything from the keratin in your toenails to the dopamine in your brain. Every living thing has its own set of genes. For example, spiders have genes for making silk, and oak trees have genes for chlorophyll, which helps them turn sunlight into energy.

The Origins of Genes

So, where do all these genes come from? Well, it depends on the gene. Scientists think that life on Earth started around 4 billion years ago with simple microbes. These early life forms had basic genes that were crucial for survival, and they passed these genes down through countless generations. Some of these ancient genes still do similar jobs in our cells today, like helping with DNA replication. However, those early microbes didn’t have genes for things like spider silk or dopamine.

How New Genes Emerge

Today, there are many more genes on Earth than there were back then. A lot of these new genes came about because of mistakes. When cells divide, they copy their DNA, and sometimes they accidentally make an extra copy of a gene. At first, this extra gene works just like the original, but over time, it can pick up mutations that change how it functions. It might even duplicate again!

Interestingly, many of our genes have evolved relatively recently, especially after humans branched off from our primate relatives. While it can take over a million years for a single gene to evolve into a family of genes, once they do, they can quickly become important.

Genes in Action

For example, we have many genes that help us detect different smells. Mutations in these genes allow us to recognize a wide variety of odors. Sometimes, mutations can cause a gene to work in a new way, like producing a protein in a different part of the body or at a different time in life.

Take snakes, for instance. They have a gene that originally made a protein to fight bacteria. Long ago, this gene duplicated, and the new copy mutated so that it started producing the protein in the snake’s mouth instead of the pancreas. This protein became part of the snake’s venom, helping it catch prey more effectively.

Creating New Genes

There are also other fascinating ways new genes can form. The DNA of animals, plants, and other organisms contains large sections that don’t code for proteins. These sections are mostly random sequences that don’t seem to do anything. However, sometimes these DNA stretches mutate and become a place where a cell can start reading them, leading to the creation of a new protein. Initially, this protein might not be very useful, but further mutations can improve it, allowing it to perform helpful functions.

Scientists have found these new genes working in different parts of animal bodies. So, our 20,000 genes have come from a mix of ancient origins and new developments. As long as life continues on Earth, new genes will keep appearing.

  1. Reflect on the concept of genes as “instruction manuals” for the body. How does this analogy help you understand the role of genes in living organisms?
  2. Consider the idea that some ancient genes still perform similar functions in our cells today. What does this suggest about the continuity and change in the evolution of life?
  3. Discuss the process by which new genes emerge through mutations and duplications. How does this process contribute to the diversity of life on Earth?
  4. Think about the example of the snake’s venom gene. How does this illustrate the potential for genes to evolve new functions over time?
  5. Explore the notion that non-coding DNA can sometimes mutate to create new genes. What implications does this have for our understanding of genetic potential and evolution?
  6. Reflect on the fact that many human genes have evolved relatively recently. How does this information shape your perspective on human evolution and our connection to other primates?
  7. Consider the role of mutations in allowing organisms to adapt to their environments. Can you think of other examples where mutations have led to significant evolutionary advantages?
  8. Discuss the idea that new genes will continue to appear as long as life exists on Earth. What does this suggest about the future of genetic research and our understanding of life?
  1. Create a Gene Timeline

    Research the history of gene development from ancient microbes to modern humans. Create a timeline that highlights key events and discoveries in the evolution of genes. Include illustrations or images to make your timeline visually engaging.

  2. Gene Mutation Simulation

    Participate in a classroom simulation where you mimic the process of gene duplication and mutation. Use colored beads or cards to represent different genes and observe how mutations can lead to new gene functions over several generations.

  3. Explore Your Genetic Traits

    Identify and list some of your own genetic traits, such as eye color or ability to roll your tongue. Research which genes are responsible for these traits and discuss how mutations might have led to variations in these genes over time.

  4. Design a New Gene

    Imagine a new gene that could provide a beneficial trait or function for humans or another organism. Describe what this gene would do, how it might have evolved, and what mutations could have led to its development.

  5. Debate: The Role of Mutations in Evolution

    Engage in a classroom debate about the role of mutations in the evolution of new genes. Discuss whether mutations are mostly beneficial, harmful, or neutral, and provide examples from the article to support your arguments.

Here’s a sanitized version of the provided YouTube transcript:

You have about 20,000 genes in your DNA. They encode the molecules that make up your body, from the keratin in your toenails to the collagen at the tip of your nose, to the dopamine in your brain. Other species have genes of their own. For example, a spider has genes for spider silk, and an oak tree has genes for chlorophyll, which helps convert sunlight into energy.

So, where did all those genes come from? It depends on the gene. Scientists believe that life began on Earth around 4 billion years ago. The earliest life forms were primitive microbes with a basic set of genes necessary for survival. They passed down these essential genes to their offspring through billions of generations. Some of these genes still perform similar functions in our cells today, such as DNA replication. However, none of those early microbes had genes for spider silk or dopamine.

There are many more genes on Earth today than there were in the past. A significant number of these additional genes originated from errors. Each time a cell divides, it creates new copies of its DNA. Occasionally, it mistakenly copies the same segment of DNA twice, resulting in an extra copy of a gene. Initially, the extra gene functions like the original, but over generations, it may accumulate new mutations. These mutations can alter how the new gene operates, and it may duplicate again.

Interestingly, many of our mutated genes have emerged relatively recently, with many evolving in the past few million years. The most recent ones evolved after our species diverged from our primate relatives. While it can take over a million years for a single gene to give rise to a family of genes, scientists are discovering that once new genes evolve, they can quickly take on essential functions.

For instance, we have numerous genes that code for proteins in our noses that detect odor molecules. Mutations allow these proteins to interact with different molecules, enabling us to perceive a vast array of smells. Sometimes, mutations can have a more significant impact on new gene copies, causing a gene to produce its protein in a different organ, at a different life stage, or to perform an entirely different function.

In snakes, for example, there is a gene that produces a protein for combating bacteria. Long ago, this gene duplicated, and the new copy mutated, altering the signal about where the protein should be produced. Instead of being active in the pancreas, it began producing this antibacterial protein in the snake’s mouth. When the snake bit its prey, this enzyme entered the wound, and as it proved beneficial for capturing prey, it became favored. Thus, a gene originally meant for the pancreas evolved to produce venom in the mouth.

There are also fascinating ways to create new genes. The DNA of animals, plants, and other organisms contains large segments that do not code for proteins. These segments are primarily random sequences of genetic material that serve no known function. Occasionally, these stretches of DNA mutate, similar to genes. Sometimes, these mutations enable the DNA to become a site where a cell can start reading it, leading to the production of a new protein. Initially, this protein may be ineffective or even detrimental, but further mutations can refine its structure, allowing it to perform useful functions that enhance an organism’s health, strength, or reproductive success.

Scientists have identified these new genes functioning in various parts of animal bodies. Thus, our 20,000 genes have diverse origins, from the beginnings of life to new genes that continue to emerge. As long as life exists on Earth, it will keep generating new genes.

This version maintains the original content’s essence while ensuring clarity and appropriateness.

GenesSegments of DNA that carry hereditary information and determine specific traits in an organism. – Scientists study genes to understand how certain traits are passed from parents to offspring.

DNADeoxyribonucleic acid, a molecule that carries the genetic instructions used in the growth, development, functioning, and reproduction of all known living organisms. – DNA is often referred to as the blueprint of life because it contains the instructions needed for an organism to develop and function.

MutationsChanges in the DNA sequence that can lead to variations in traits or sometimes cause diseases. – Some mutations can be beneficial and lead to new adaptations in a species over time.

ProteinsLarge, complex molecules made up of amino acids that perform many critical functions in living organisms, including catalyzing metabolic reactions and supporting cellular structure. – Enzymes are proteins that speed up chemical reactions in the body.

EvolutionThe process by which different kinds of living organisms are thought to have developed and diversified from earlier forms during the history of the earth. – The theory of evolution explains how species adapt to their environments over generations.

MicrobesMicroscopic organisms, such as bacteria, viruses, and fungi, that can be found in various environments and play essential roles in ecosystems. – Microbes in the soil help decompose organic matter, returning nutrients to the ecosystem.

OrganismsIndividual living entities that can react to stimuli, reproduce, grow, and maintain homeostasis. – All organisms, from the smallest bacteria to the largest whales, are part of the Earth’s biosphere.

EnergyThe capacity to do work, which in biological systems is often derived from the metabolism of nutrients. – Plants convert sunlight into chemical energy through the process of photosynthesis.

SurvivalThe ability of an organism to continue living and reproduce in its environment. – Adaptations such as camouflage can enhance an animal’s survival by helping it avoid predators.

SmellsOdors or scents that are detected by the olfactory system, often used by organisms to find food, mates, or detect danger. – Many flowers emit pleasant smells to attract pollinators like bees and butterflies.

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